American Journal of Advanced Multidisciplinary Research and Innovation

E-ISSN: XXXX-XXXX   •   Impact Factor: -

A Widely Indexed Open Access Peer Reviewed Multidisciplinary Bi-monthly Scholarly International Journal

Call for Paper Volume 8, Issue 5 (September-October 2026) Submit your research before last 3 days of October to publish your research paper in the issue of September-October.
Submit Research Paper Join as a Reviewer

Plagiarism is checked by the leading plagiarism checker TurnItIn

Call for Paper

Volume 8 Issue 5
September-October 2026

Submit your research paper

Indexing Partners
Academia Advanced Sciences Index Bielefeld Academic Search Engine CiteSeer DRJI Google Scholar Independent Search Engine & Directory Network ISI (International Scientific Indexing) Issuu Mendeley Research Networks
RefSeek ResearcherId - Thomson Reuters ResearchGate Scirus Scribd Semantic Scholar UTeM - Universiti Teknikal Malaysia Melaka Wiki for Call for Papers WorldCat Zenodo

Personalized mRNA Therapeutics: Integrating Artificial Intelligence, Genomics and Precision Healthcare

Author(s) Solène Delecourt
Country United States
Abstract Personalized mRNA therapeutics represent an emerging frontier in precision medicine, combining messenger RNA technology with genomics, artificial intelligence, and individualized clinical decision-making. Unlike conventional pharmaceutical approaches, mRNA platforms can be rapidly designed to encode therapeutic proteins, antigens, or other biologically relevant molecules, creating opportunities for patient-specific interventions. Advances in genomic sequencing, computational biology, machine learning, and lipid nanoparticle delivery are increasingly enabling the identification of molecular targets and the development of individualized mRNA constructs. This paper examines the technological foundations of personalized mRNA therapeutics and evaluates their potential applications in cancer immunotherapy, rare diseases, infectious diseases, protein replacement, and regenerative medicine. A qualitative and conceptual methodology is adopted to analyse the integration of genomics, artificial intelligence, mRNA design, delivery systems, and clinical decision-making. The analysis indicates that AI can support target identification, sequence optimisation, neoantigen prediction, patient stratification, and treatment-response modelling, while genomic information provides the molecular basis for individualised therapeutic design. Major challenges include delivery efficiency, RNA stability, immunogenicity, manufacturing scalability, computational bias, genomic privacy, regulatory complexity, and equitable access. The study proposes an integrated precision-mRNA framework connecting genomic profiling, AI-assisted target selection, computational sequence design, personalised manufacturing, and clinical monitoring. The paper concludes that personalized mRNA therapeutics could significantly expand the scope of precision healthcare, provided that technological innovation is accompanied by rigorous clinical validation, secure genomic-data governance, scalable manufacturing, and responsible regulatory frameworks.
Keywords : Personalized mRNA Therapeutics, Artificial Intelligence, Genomics, Precision Medicine, mRNA Technology, Cancer Immunotherapy, Lipid Nanoparticles, Machine Learning, Precision Healthcare, Personalized Medicine.
Field Engineering
Published In Volume 6, Issue 1, January-February 2024
Published On 2024-02-02
View / Download PDF File

Share this



E-ISSN XXXX-XXXX
CrossRef

CrossRef DOI prefix of AJAMRI is 10.00000/AJAMRI

Downloads
Research Paper Format Copyright Permission Form and Undertaking Form

All research papers published on this website are licensed under Creative Commons Attribution-ShareAlike 4.0 International License, and all rights belong to their respective authors/researchers.

CC-BY-SA Open Access

About AJAMRI
Fees & Payment
Current Issue
Publication Archive 		Submit Research Paper
Track Submission Status
Publication Guidelines
Publication Ethics
Peer Review & Plagiarism 		Join as a Reviewer
Editors & Reviewers
Reviewer Referral Program
Get Reviewer Membership Certi. 		Website/Journal Policies
Usage Policy
Content Policies
Privacy Policy
Contact Us +1-872-302-3851 editor@ajamri.com